bzATP

**bzATP** is a synthetic small molecule analogue of adenosine triphosphate (ATP) where the ribose is substituted at the 2'/3' position with a 4-benzoylbenzoyl group. It acts as a prototypic and potent **agonist** of the **P2X7 receptor** (EC50 varies by species), exhibiting significantly greater potency than ATP. It also has partial agonist activity at **P2X1** and **P2Y1** receptors. bzATP is commonly used in research settings to study purinergic signaling, especially for functions mediated by the P2X7 receptor, including cytolytic responses and inflammatory mechanisms. Additionally, bzATP serves as a photoaffinity probe for ATPase enzymes. The drug is not approved for therapeutic use and is used solely for laboratory research[1][3][5][6][8][9].

Other names

benzoylbenzoyl-ATPBzATP triethylammonium salt3'-O-(4-Benzoyl)benzoyl ATP3'-O-(4-Benzoyl)benzoyladenosine 5'-triphosphate2'-3'-O-(4-Benzoylbenzoyl)adenosine 5'-triphosphatebenzoylbenzoyl-ATP triethylammonium salt2'(3')-O-(4-benzoylbenzoyl)adenosine 5'-triphosphate triethylammonium salt