C-176

C-176 is a potent and selective small molecule covalent inhibitor of the stimulator of interferon genes (STING) pathway. It acts by covalently binding to cysteine residue 91 on murine STING, thereby blocking activation-induced palmitoylation and downstream signaling. This inhibition reduces STING-mediated type I interferon responses without affecting other pathways such as RIG-I or TBK1. C-176 is blood-brain barrier permeable and has demonstrated anti-inflammatory effects in preclinical models by suppressing immune responses associated with autoinflammatory diseases and inflammatory osteolysis[1][3][5][7]. It has also shown efficacy in reducing endometrial fibrosis in animal studies[4]. The compound was originally developed at École Polytechnique Fédérale de Lausanne.

Other names

N-(4-Iodophenyl)-5-nitro-2-furancarboxamideSting inhibitor 1Sting inhibitor C-176