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c-ATT regimen (Sun Yat-sen University)
- Development stage
- Phase 3
- Lead developer
- Sun Yat-sen University
- Modality
- Small Molecules
- Administration
- Intravenous, Oral
01
Overview
c-ATT is an intensive sequential chemotherapy regimen developed by Sun Yat-sen University for the treatment of untreated high-risk T-cell lymphoma. The regimen consists of three alternating protocols administered sequentially: CHOP-B (cyclophosphamide, doxorubicin, vincristine, prednisone, and bleomycin), IMVP-16 (ifosfamide, methotrexate, and etoposide), and DHAP (dexamethasone, cytarabine, and cisplatin). This approach is designed to improve therapeutic efficacy over standard CHOP therapy by utilizing a broad range of non-cross-resistant cytotoxic agents to overcome drug resistance in aggressive T-cell lymphomas.
- Other names
- CHOP-B/IMVP-16/DHAP regimen
02
Targets
CRBN (Cereblon)DNADNA polymerase familyTOP2A (DNA topoisomerase II)DHFR (Dihydrofolate reductase)GR (Glucocorticoid receptor)TUBB (Tubulin (alpha and beta subunits))
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