C-DIM5

C-DIM5 is a synthetic small molecule belonging to the family of para-phenyl–substituted diindolylmethanes. It acts as an agonist for the orphan nuclear receptor Nur77 and also recruits Nurr1 in neural cells. The neuroprotective and anti-inflammatory efficacy is mediated through upregulation of Nur77 mRNA, suppression of neuroinflammatory genes, and inhibition of NF-κB–dependent expression of inflammatory and apoptotic targets. C-DIM5 prevents nuclear export of Nur77 and recruits Nurr1 to the nucleus, leading to transrepressive effects on inflammatory signaling. It has demonstrated efficacy in preventing loss of dopaminergic neurons in mouse models of Parkinson’s disease and can induce apoptosis in colon cancer cells. Administration is typically oral, and its pharmacokinetic profile has been studied in murine models[1][4][5][7].

Other names

1,1-bis(3′-indolyl)-1-(p-methoxyphenyl)methane