C-dot nanozyme

C-dot nanozymes are nanomaterials composed of carbon dots (CDs) that exhibit intrinsic enzyme-like catalytic activities. These quantum-sized nanoparticles can mimic natural enzymes such as superoxide dismutase (SOD), peroxidase, and oxidase. Their mechanism of action involves catalyzing redox reactions—such as the conversion of superoxide anions and hydrogen peroxide—leading to the regulation of reactive oxygen species (ROS) within biological systems. This property enables them to disturb oxidative homeostasis in tumor cells or protect neurons from oxidative stress. C-dot nanozymes have been engineered for various biomedical applications: - As drug carriers for co-delivery systems combining chemotherapeutics (e.g., doxorubicin) and siRNA to overcome drug resistance in cancers by suppressing targets like MRP1 and oxidizing glutathione[1]. - As antibacterial agents through peroxidase-mimetic activity that generates ROS toxic to bacteria[2]. - As neuroprotective agents by scavenging ROS in neurological diseases such as ischemic stroke or Alzheimer's disease[3]. Surface modifications—including doping with metals or functionalization with aptamers—can further enhance their catalytic efficiency and targeting capabilities[4]. They are noted for high biocompatibility, low cytotoxicity, stable chemical inertness, water dispersibility, and tunable surface chemistry.

Other names

carbon dot nanozymeCD-based nanozymeCDs-based nanozymecarbon dots (CDs) with enzyme-like activity