c-Met shRNA

c-Met shRNA (short hairpin RNA targeting the hepatocyte growth factor receptor, c-Met) is a gene-silencing therapeutic platform designed to downregulate the expression of the c-Met receptor tyrosine kinase. By specifically targeting c-Met mRNA for degradation, c-Met shRNA inhibits the HGF/c-Met signaling pathway, which is frequently dysregulated in various malignancies and plays a critical role in tumor cell proliferation, survival, migration, invasion, and metastasis (such as breast cancer-derived bone metastases). This RNA interference strategy is typically delivered via viral vectors (such as lentiviruses, retroviruses, or adenoviruses) or non-viral nanoparticles, and has been investigated in preclinical research both as a monotherapy and in combination with small-molecule c-Met inhibitors like tivantinib.

Other names

c-MET shRNAc-Met short hairpin RNAshMetshRNA against c-Met