C-peptide-conjugated solid lipid nanoparticles

C-peptide-conjugated solid lipid nanoparticles are a nanotechnology-based drug delivery system in which a specific peptide (in this case, a C-peptide derived from endostatin) is chemically conjugated to the surface of solid lipid nanoparticles (SLNs). This design enables targeted delivery by exploiting the affinity of the conjugated peptide for particular cellular receptors, such as integrin αvβ3. The primary mechanism involves enhanced binding and uptake by target cells expressing these receptors, improving therapeutic efficacy and reducing off-target effects. These systems are under investigation for applications including targeted cancer therapy and potentially other diseases where receptor-mediated targeting can improve drug localization[1][3]. The technology is still experimental and not yet approved for clinical use.

Other names

C-peptide SLNspeptide-functionalized solid lipid nanoparticles