C-Radboud University Medical Center-influenza

C-Radboud University Medical Center-influenza refers to a specific investigational vaccine regimen evaluated by the Radboud University Medical Center. This regimen involves the sequential administration of the Bacillus Calmette-Guérin (BCG) vaccine followed by a seasonal influenza vaccine. The primary objective is to leverage the concept of "trained immunity" induced by BCG—characterized by epigenetic and metabolic reprogramming of innate immune cells such as monocytes and natural killer cells—to non-specifically enhance the subsequent adaptive immune response to the influenza vaccine. This pilot proof-of-principle study aims to determine if prior BCG vaccination can improve the immunogenicity and protective efficacy of influenza vaccination, particularly in populations with waning immunity.

Other names

BCG + Influenza VaccineBCG-Influenza RegimenBCG Vaccination and Influenza Vaccine Response