C-terminal fibroblast growth factor 23 fragment

C-terminal fibroblast growth factor 23 fragment (cFGF23) is a naturally occurring peptide fragment generated by the proteolytic cleavage of intact fibroblast growth factor 23 (iFGF23) at its RXXR motif. It acts as a competitive antagonist of iFGF23 by binding to the binary FGF receptor (FGFR)-Klotho complex, thereby blocking downstream FGF23 signaling. In preclinical models, cFGF23 has been investigated as a therapeutic agent to treat bone mineralization defects, restore hematopoietic stem cell (HSC) bone marrow niche function in beta-thalassemia, and mitigate kidney inflammation and cardiomyopathy associated with pathological FGF23 excess.

Other names

C-terminal FGF23 fragmentC-terminal FGF23 peptideFGF23 C-terminal tail peptideFGF-23 C-terminal tail peptideFGF 23 C-terminal tail peptideFGF23 C-tail peptideFGF-23 C-tail peptideFGF 23 C-tail peptideFGF23 blocking peptideFGF-23 blocking peptideFGF 23 blocking peptidecarboxyl-terminal FGF23 peptidecFGF23cFGF-23cFGF 23