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C019199 + sintilimab
- Development stage
- Unknown
- Lead developer
- Haixi New Pharma
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Oral, Intravenous
01
Overview
C019199 + sintilimab is an investigational combination therapy being developed by Fujian Haixi Pharmaceuticals for the treatment of advanced solid tumors, including colorectal cancer, pancreatic cancer, gastric cancer, esophageal squamous cell carcinoma, and head and neck squamous cell carcinoma. C019199 is a small molecule multi-targeted kinase inhibitor that targets colony-stimulating factor 1 receptor (CSF-1R), discoidin domain receptor 1 (DDR1), and vascular endothelial growth factor receptor 2 (VEGFR2). Sintilimab is a monoclonal antibody that blocks the programmed cell death protein 1 (PD-1) receptor. The combination aims to enhance anti-tumor immune responses by simultaneously inhibiting immunosuppressive pathways in the tumor microenvironment and promoting T-cell activation. It is currently in Phase 1 clinical development.
- Other names
- C019199 + PD-1 inhibitorC019199 combination with anti-PD-1C-019199 combination with anti-PD-1C 019199 combination with anti-PD-1
02
Targets
CSF1R (Macrophage colony-stimulating factor receptor)VEGFR2 (Vascular endothelial growth factor receptor 2)DDR1 (Discoidin domain receptor 1)PDCD1 (Programmed cell death protein 1 receptor)
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