C12-iE-DAP

C12-iE-DAP is a synthetic, cell-permeable acylated derivative of the peptidoglycan dipeptide iE-DAP (gamma-D-Glu-mDAP). It acts as a potent and specific agonist for the Nucleotide-binding Oligomerization Domain-containing protein 1 (NOD1), an intracellular pattern recognition receptor. By mimicking bacterial motifs, C12-iE-DAP triggers the NOD1 signaling pathway, leading to the activation of NF-κB and MAPK pathways, and the production of inflammatory cytokines. In the context of immune thrombocytopenia (ITP) during pregnancy, it has been investigated for its ability to ameliorate bone marrow mesenchymal stem cell (BM-MSC) injury and promote platelet production via the IFN-I/STAT1 signaling cascade. The molecule incorporates a lauroyl (C12) fatty acid chain to enhance membrane permeability compared to the parent dipeptide.

Other names

lauroyl-gamma-D-glutamyl-meso-diaminopimelic acidlauroyl-iE-DAPNOD1 agonistNOD-1 agonistNOD 1 agonistNOD1 ligandNOD-1 ligandNOD 1 ligand