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C21 IT

Development stage: Discontinued
Lead developer: our laboratory
Modality: Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Immunotoxins → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intraperitoneal Injection

Overview

C21 IT is a truncated diphtheria toxin DT390-based immunotoxin. It is described as an "unrelated IT" and was used as a negative control in studies evaluating the efficacy of other immunotoxins targeting cutaneous T-cell lymphoma (CTCL). Its mechanism of action involves the cytotoxic effects of diphtheria toxin, which inhibits protein synthesis.

Targets

EEF2 (Eukaryotic elongation factor 2)

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