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C2E2
- Development stage
- Unknown
- Lead developer
- Captura Biopharma
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
C2E2 is an orally bioavailable chelating agent being developed by Captura Biopharma for the decorporation of transuranic radionuclides, such as plutonium, americium, and curium, following internal contamination. Developed based on research from the University of North Carolina, C2E2 is designed to be the first oral treatment suitable for mass casualty situations, such as nuclear power accidents or dirty bomb detonations. It serves as a more practical alternative to existing intravenous or nebulized chelating agents like diethylenetriaminepentaacetic acid (DTPA). C2E2 functions by binding to radioactive isotopes in the body to form stable, water-soluble complexes that are subsequently excreted, thereby reducing the internal radiation dose.
- Other names
- diethyl ester of DTPA
02
Targets
TRU (Transuranic actinide)
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