c3 transferase

C3 transferase is a **bacterial exoenzyme** derived from *Clostridium botulinum*, known for its ability to irreversibly inhibit the small GTPase **RhoA** (and also RhoB and RhoC) via **ADP ribosylation** at asparagine 41[1][2][3]. This inhibition leads to cytoskeletal reorganization, stimulation of neurite and axonal outgrowth, and neuroprotection. C3 transferase is a protein of approximately 24 kDa, commonly used experimentally to inhibit RhoA signaling in models of central nervous system injury and Parkinson's disease[1][2][3]. Therapeutically, cell-permeable and viral vector formats have been studied, primarily for application in neural repair and regeneration, including spinal cord injury and experimental cell replacement therapy in Parkinson's disease[1][3]. Modified ("Cethrin") versions are in development for localized delivery to the CNS, with ongoing investigation into gene therapy and protein delivery approaches[1][3]. No major adverse effects have been observed in continuous expression or targeted delivery studies.

Brand names

Cethrin

Other names

exoenzyme c3 transferasec3c-3c 3c3 exoenzymec-3 exoenzymec 3 exoenzymec3 toxinc-3 toxinc 3 toxin