C4BPA recombinant protein

C4BPA (C4b-binding protein alpha chain) is a protein identified as a key mediator of muscle degeneration in Duchenne muscular dystrophy (DMD). It is secreted at elevated levels by pathological fibroadipogenic precursor cells (FAPs) within the dystrophic muscle environment. Recombinant C4BPA is used in research to demonstrate its potent anti-myogenic effects, which include the impairment of myotube formation, downregulation of myogenic markers, and reduction of contractile function in muscle models. Because silencing or neutralizing C4BPA has been shown to restore myogenic capacity and improve muscle differentiation, it is currently being investigated as a novel therapeutic target to preserve muscle regeneration and mitigate the fibrotic progression associated with DMD.

Other names

C4b-binding protein alpha chainC-4b-binding protein alpha chainC 4b-binding protein alpha chainC4BP alphaC-4BP alphaC 4BP alphaC4BPAC-4BPAC 4BPArecombinant C4BPA