CA-074

CA-074 is a potent, highly selective, and irreversible inhibitor of cathepsin B, a lysosomal cysteine protease. Originally developed by Nobuhiko Katunuma's group at Tokushima University, CA-074 is an epoxysuccinyl peptide derivative designed based on the structure of E-64. It selectively targets the active site of cathepsin B with nanomolar potency (Ki of 2–5 nM), showing several thousand-fold selectivity over other cysteine cathepsins such as cathepsin H, L, and S. CA-074 is widely utilized as a research tool to investigate the role of cathepsin B in various physiological and pathological processes, including lysosomal protein degradation, autophagy, antigen presentation, tumor invasion, metastasis, and neurodegenerative diseases like Alzheimer's disease.

Other names

(2S)-1-[(2S,3S)-3-methyl-2-[[(3S)-3-(propylcarbamoyl)oxirane-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carboxylic acidL-trans-Epoxysuccinyl-Ile-Pro-OH propylamideN-(L-3-trans-propylcarbamoyloxirane-2-carbonyl)-L-isoleucyl-L-proline