CA7-LP

CA7-LP is a liposomal formulation of CA7, a synthetic monocarbonyl analog of curcumin, developed to improve the compound's stability, solubility, and pharmacokinetic profile for the treatment of cervical cancer. The formulation consists of CA7 encapsulated within lipid vesicles, resulting in spherical nanoparticles with an average diameter of approximately 92 nm. Preclinical studies demonstrate that CA7-LP significantly enhances cellular uptake in HeLa cells compared to free CA7, leading to potent inhibition of cell proliferation and migration, cell cycle arrest, and the induction of apoptosis. In vivo, CA7-LP shows superior pharmacokinetics, including a 3.58-fold increase in AUC and a 5.65-fold increase in Cmax compared to the free drug. Its anti-tumor efficacy in mouse models is comparable to cisplatin but with a more favorable safety profile, suggesting high potential for clinical application in cervical cancer therapy.

Other names

CA7-loaded liposomesCA-7-loaded liposomesCA 7-loaded liposomesliposomal CA7