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cabazitaxel ginsenoside liposome injection
- Development stage
- Phase 4
- Lead developer
- Hangzhou Jinshennuo Biopharmaceutical
- Modality
- Small Molecules, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
Cabazitaxel ginsenoside liposome injection (Ginposome-CTX) is an innovative liposomal formulation of the taxane chemotherapy agent cabazitaxel, developed by Xiamen Ginposome Pharmaceutical. The drug utilizes a proprietary ginsenoside-based liposome delivery system (Ginposome DDS), where ginsenosides (specifically ginsenoside Rg3) replace cholesterol as the membrane-stabilizing material. This approach is designed to improve the pharmacokinetic profile of cabazitaxel and potentially enhance therapeutic efficacy through the intrinsic anti-tumor properties of ginsenosides. Cabazitaxel functions by binding to and stabilizing tubulin within microtubules, preventing their disassembly and leading to cell cycle arrest and apoptosis. The product is administered intravenously and is currently in the NDA filing stage in China for the treatment of prostate cancer.
- Other names
- 注射用复方卡巴他赛人参皂苷脂质体Cabazitaxel + liposomal ginsenoside
02
Targets
SLC2A4 (Solute carrier family 2 facilitated glucose transporter member 4)TUBB (Tubulin (alpha and beta subunits))
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