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cabotegravir prodrug
- Development stage
- Preclinical
- Lead developer
- University of Nebraska Medical Center
- Modality
- Nanoparticles → Drug Delivery Systems, Small Molecules
- Administration
- Intramuscular
01
Overview
Cabotegravir prodrug is a modified form of cabotegravir designed to extend the drug's release profile beyond the current monthly administration. The prodrug consists of fatty acid ester modifications of cabotegravir with added carbon chains (14, 18, or 22 carbons) encased in biocompatible surfactants (poloxamer coating). These modifications create hydrophobic and lipophilic versions with controlled hydrolysis and tissue penetrance properties. The lead formulation, NM2CAB (18-carbon ester chain), has demonstrated plasma cabotegravir levels above the protein-adjusted 90% inhibitory concentration for up to a year in pharmacokinetic studies performed in mice and rhesus macaques.
- Other names
- fatty acid ester CAB nanocrystal prodrugs
02
Targets
Integrase allosteric pocket (HIV)
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