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cabozantinib + temozolomide
- Development stage
- Phase 2
- Lead developer
- Northwestern University
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination therapy consisting of cabozantinib, a multi-tyrosine kinase inhibitor targeting VEGFR2, MET, AXL, RET, KIT, FLT3, and TIE-2, and temozolomide, an alkylating agent that damages DNA in cancer cells. This combination has demonstrated synergistic anticancer effects in preclinical studies and clinical trials, particularly for soft tissue sarcomas including leiomyosarcoma. The dual targeting of VEGF and c-MET pathways with cabozantinib, combined with temozolomide's DNA-damaging effects, produces a synergistic antitumor effect.
02
Targets
AXL (AXL receptor tyrosine kinase)DNAFLT3 (Fms related receptor tyrosine kinase 3)KIT (c-KIT proto-oncogene receptor tyrosine kinase)MET (Mesenchymal-epithelial transition factor receptor)RET (Rearranged during transfection receptor tyrosine kinase)TEK (Tie2)VEGFR2 (Vascular endothelial growth factor receptor 2)
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