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Drug intelligence / Profile preview
cabozantinib + nivolumab
- Development stage
- Phase 4
- Lead developer
- Exelixis
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Cabozantinib + nivolumab is a fixed combination regimen of two distinct drugs used for the treatment of advanced renal cell carcinoma (RCC). Cabozantinib is an oral small molecule tyrosine kinase inhibitor that targets multiple kinases, including vascular endothelial growth factor receptors (VEGFRs), MET, and AXL, thereby inhibiting tumor angiogenesis and proliferation. Nivolumab is a monoclonal antibody immune checkpoint inhibitor targeting programmed death 1 (PD-1) receptor on T cells, enhancing anti-tumor immune responses. The combination leverages both direct anti-tumor effects via kinase inhibition and immunomodulation to improve clinical outcomes in patients with advanced RCC. This regimen has demonstrated significant improvements in progression-free survival, overall survival, and objective response rate compared to sunitinib in first-line therapy for advanced RCC[1][2][3][4][5][8].
- Brand names
- Cabometyx + Opdivo
- Other names
- cabozantinib plus nivolumabNIVO + CABOOpdivo plus Cabometyx
02
Targets
AXL (AXL receptor tyrosine kinase)KIT (c-KIT proto-oncogene receptor tyrosine kinase)MET (Mesenchymal-epithelial transition factor receptor)PDCD1 (Programmed cell death protein 1 receptor)RET (Rearranged during transfection receptor tyrosine kinase)ROS1 (Proto-oncogene tyrosine-protein kinase ROS)TEK (Tie2)VEGFR2 (Vascular endothelial growth factor receptor 2)
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