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Cacicol 20
- Development stage
- Unknown
- Lead developer
- Théa Pharmaceuticals
- Modality
- Injectable Hydrogels → Hydrogel Systems → Drug Delivery Systems, Implantable Hydrogels → Hydrogel Systems → Drug Delivery Systems, Non-biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Ophthalmic
01
Overview
Cacicol 20 is a topical ophthalmic regenerative agent classified as the first ReGeneraTing Agent (RGTA) for ophthalmic use. Its active component is poly(carboxymethylglucose sulfate), a biopolymer that mimics the structure and function of heparan sulfate glycosaminoglycans (HS GAGs), which are natural constituents of the extracellular matrix. By mimicking HS, Cacicol 20 helps restore and protect the extracellular matrix, promoting cellular communication, cellular homeostasis, and tissue repair. It is indicated for the treatment of corneal dystrophies, chronic corneal ulcers, neurotrophic corneal ulcers, and to accelerate corneal wound healing and nerve regeneration following surgical procedures like phototherapeutic keratectomy or corneal cross-linking[1][3][5][7].
- Brand names
- CacicolCacicol 20Cacicol20Cacicol-20
- Other names
- Poly(carboxymethylglucose sulfate)regenerating agentRGTA
02
Targets
MMP12 (Macrophage Metalloelastase)
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