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cAd3-EBO S
- Development stage
- Phase 2
- Lead developer
- Sabin Vaccine Institute
- Modality
- DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
cAd3-EBO S is an investigational vaccine designed to protect against the Sudan virus (SUDV), a species of Ebola virus. It uses a non-replicating chimpanzee adenovirus type 3 (cAd3) vector to deliver genetic material encoding the glycoprotein of the Sudan virus. This induces an immune response by prompting the body to produce antibodies and T cell responses specific to the viral glycoprotein. The vaccine has demonstrated safety and immunogenicity in phase 1 clinical trials, rapidly inducing durable antibody and T cell responses after a single intramuscular injection. It is being developed for emergency deployment in regions at risk for SUDV outbreaks[1][5].
- Other names
- chimpanzee adenovirus type 3 Ebola Sudan vaccinecAd3-SUDVcAd-3-SUDVcAd 3-SUDVcAd3-SudancAd-3-SudancAd 3-Sudan
02
Targets
Zaire ebolavirus glycoprotein
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