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cadonilimab + axitinib
- Development stage
- Phase 2
- Lead developer
- Akeso
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
Cadonilimab + axitinib is a combination therapy consisting of cadonilimab (AK104), a bispecific antibody targeting both PD-1 and CTLA-4 immune checkpoints, and axitinib, a tyrosine kinase inhibitor that targets VEGFR. Cadonilimab was designed to achieve preferential binding to tumor-infiltrating lymphocytes rather than normal peripheral tissue lymphocytes. This combination therapy targets both immune checkpoint inhibition and angiogenesis pathways simultaneously.
02
Targets
CTLA-4 (Cytotoxic t-lymphocyte–associated protein 4)PDCD1 (Programmed cell death protein 1 receptor)PDGFRB (Platelet-derived growth factor receptor beta)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)KIT (c-KIT proto-oncogene receptor tyrosine kinase)
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