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cadonilimab + carboplatin + pemetrexed
- Development stage
- Phase 2
- Lead developer
- Akeso
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
Cadonilimab (AK104) is a human tetravalent bispecific IgG1 antibody designed to simultaneously block the PD-1 and CTLA-4 immune checkpoints. It features an Fc-null design to minimize immune-related toxicities by eliminating Fc receptor-mediated effector functions such as ADCC, ADCP, CDC, and cytokine release. Cadonilimab is developed by Akeso and has demonstrated biological activity similar to the combination of separate anti-PD-1 and anti-CTLA-4 antibodies but with reduced toxicity. Carboplatin is a platinum-based chemotherapy agent that induces DNA crosslinking leading to apoptosis in cancer cells. Pemetrexed is an antifolate chemotherapeutic that inhibits multiple folate-dependent enzymes involved in nucleotide synthesis. The combination of these agents aims to enhance antitumor efficacy through both direct cytotoxic effects (carboplatin and pemetrexed) and immune modulation (cadonilimab). This regimen is under investigation for advanced solid tumors including non-small cell lung cancer[1][5][3].
- Other names
- cadonilimab + carboplatin + pemetrexed
02
Targets
CTLA-4 (Cytotoxic t-lymphocyte–associated protein 4)DNADHFR (Dihydrofolate reductase)PDCD1 (Programmed cell death protein 1 receptor)TS (Thymidylate synthase)GART (GAR transformylase)
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