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Drug intelligence / Profile preview
cadonilimab + fruquintinib + paclitaxel-albumin
- Development stage
- Phase 2
- Lead developer
- Kangfang Sainuo Pharmaceutical
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous, Oral
01
Overview
This is a combination regimen consisting of three agents: cadonilimab, fruquintinib, and paclitaxel-albumin. Cadonilimab is a bispecific monoclonal antibody targeting both PD-1 and CTLA-4 immune checkpoints, designed to enhance antitumor immune responses. Fruquintinib is an oral small molecule inhibitor of vascular endothelial growth factor receptors 1, 2, and 3 (VEGFR1/2/3), which blocks angiogenesis in tumors. Paclitaxel-albumin (nab-paclitaxel) is a nanoparticle formulation of the chemotherapy agent paclitaxel bound to human serum albumin; it disrupts microtubule function during cell division, leading to cancer cell death. This combination aims to leverage immunotherapy with antiangiogenic therapy and cytotoxic chemotherapy for synergistic antitumor effects.
- Brand names
- Abraxane (paclitaxel-albumin)
- Other names
- paclitaxel protein-bound particles for injectable suspensionnanoparticle albumin-bound paclitaxelprotein-bound paclitaxel
02
Targets
CTLA-4 (Cytotoxic t-lymphocyte–associated protein 4)PDCD1 (Programmed cell death protein 1 receptor)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)TUBB (Tubulin (alpha and beta subunits))
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