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cadonilimab + pemetrexed + anlotinib
- Development stage
- Unknown
- Lead developer
- Akeso
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
This combination involves **cadonilimab**, a PD-1/CTLA-4 bispecific antibody, **pemetrexed**, a chemotherapy drug, and **anlotinib**, a multi-targeted tyrosine kinase inhibitor. Cadonilimab works by blocking PD-1 and CTLA-4 pathways to enhance T-cell responses. Pemetrexed is used in chemotherapy to treat various cancers. Anlotinib targets multiple kinases involved in tumor growth and angiogenesis.
02
Targets
PDCD1 (Programmed cell death protein 1 receptor)TS (Thymidylate synthase)VEGFR2 (Vascular endothelial growth factor receptor 2)DHFR (Dihydrofolate reductase)PDGFRB (Platelet-derived growth factor receptor beta)CTLA-4 (Cytotoxic t-lymphocyte–associated protein 4)GART (GAR transformylase)KIT (c-KIT proto-oncogene receptor tyrosine kinase)VEGFR3 (Vascular endothelial growth factor receptor 3)
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