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Drug intelligence / Profile preview
CAF09b
- Development stage
- Unknown
- Lead developer
- Statens Serum Institut
- Modality
- Liposomes → Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intramuscular, Intranasal, Intraperitoneal
01
Overview
CAF09b is a **cationic liposomal vaccine adjuvant** developed by Statens Serum Institut. It comprises dimethyldioctadecylammonium bromide, monomycoloyl glycerol, and polyinosinic:polycytidylic acid. The formulation is designed to enhance antigen-specific cellular immunity, particularly cytotoxic CD8-positive T-cell responses, through innate immune activation and liposomal antigen delivery. CAF09b has been evaluated as an adjuvant in personalized neoantigen cancer vaccines, a Bcl-xL peptide vaccine for prostate cancer, and the CTH522 vaccine for trachoma and chlamydial infection. Croda holds an exclusive license to manufacture and commercialize the CAF adjuvant portfolio, including CAF09b. ([vac.niaid.nih.gov](https://vac.niaid.nih.gov/view?id=76))
- Other names
- CAF 09bCAF09bCAF-09bCAF®09bcationic adjuvant formulation 09b
02
Targets
CLEC4E (Macrophage-inducible C-type lectin receptor)TLR3 (Toll-like receptor 3)
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