Drug intelligence / Profile preview

caffeine + tolbutamide + omeprazole + dextromethorphan + digoxin + midazolam

Development stage: Unknown
Lead developer: AstraZeneca
Modality: Small Molecules
Administration: Oral

Overview

A six-probe drug cocktail used in clinical research to simultaneously assess the activity of multiple drug metabolizing enzymes and transporters. Each component targets specific metabolic pathways: - Caffeine is used to assess CYP1A2 activity - Tolbutamide is used to assess CYP2C9 activity - Omeprazole is used to assess CYP2C19 activity - Dextromethorphan is used to assess CYP2D6 activity - Midazolam is used to assess CYP3A4 activity - Digoxin is used to assess P-glycoprotein transporter activity This approach enables researchers to evaluate individual variations in drug metabolism and pharmacokinetics, supporting the development of personalized medicine approaches.

Other names: six-probe cocktailCooperstown W/T CYP cocktailCIME combination

Targets

CYP2C19 (Cytochrome P450 2C19)ABCB1 (P-glycoprotein)CYP1A2 (Cytochrome P450 1A2)CYP3A4 (Cytochrome P450 3A4)CYP2C9 (Cytochrome P450 family 2 subfamily C member 9)

Beyond the preview

Go deeper on caffeine + tolbutamide + omeprazole + dextromethorphan + digoxin + midazolam.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on caffeine + tolbutamide + omeprazole + dextromethorphan + digoxin + midazolam.

Explore the full profile