Drug intelligence / Profile preview

caffeine + chlorpheniramine + paracetamol + phenylephrine

Development stage
Unknown
Lead developer
Juggat Pharma
Modality
Small Molecules
Administration
Oral
01

Overview

B-Hold Tablets is an oral fixed-dose combination therapy developed by Juggat Pharma (a division of Jagdale Industries) for the symptomatic relief of the common cold, nasal congestion, sneezing, and runny nose. The formulation contains four active ingredients: paracetamol (500 mg), phenylephrine hydrochloride (5 mg), chlorpheniramine maleate (2 mg), and caffeine (15 mg). Paracetamol acts as an analgesic and antipyretic by inhibiting cyclooxygenase (COX) enzymes to reduce pain and fever. Phenylephrine is a selective alpha-1 adrenergic receptor agonist that acts as a nasal decongestant by causing vasoconstriction in the nasal mucosa. Chlorpheniramine is a first-generation histamine H1 receptor antagonist that alleviates allergic symptoms such as sneezing and runny nose. Caffeine serves as a central nervous system stimulant and adenosine receptor antagonist, which enhances the analgesic efficacy of paracetamol and counteracts the sedative effects of chlorpheniramine.

Brand names
B-HoldB-Hold Tablets
Other names
caffeine + chlorpheniramine + paracetamol + phenylephrinecaffeine + chlorpheniramine maleate + paracetamol + phenylephrine hydrochlorideparacetamol + phenylephrine + chlorpheniramine + caffeine
02

Targets

ADORA1 (Adenosine receptor A1 subtype)ADORA2A (Adenosine A₂A Receptor)ADORA2B (Adenosine A2B receptor)ADORA3 (Adenosine A3 receptor)ADRA1A (α1A)ADRA1B (α1B)ADRA1D (α1D)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)HRH1 (Histamine H1 Receptor)

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