caffeine + curcumin

**Caffeine + curcumin** is a combination of two small molecule compounds: caffeine, a methylxanthine with central nervous system stimulant and anti-inflammatory activity, and curcumin, a polyphenolic phytochemical from turmeric with notable antioxidant, anti-inflammatory, and antipsoriatic effects. In topical nanosponge gel formulation, this combination has shown **augmented anti-psoriatic activity and faster onset of therapeutic effect compared to curcumin alone**, particularly in a mouse model of imiquimod-induced psoriasis. Mechanistically, caffeine acts primarily as a **phosphodiesterase inhibitor, increasing intracellular cAMP concentrations and suppressing inflammatory pathways**, while curcumin modulates phosphorylase kinase activity, various cell signaling pathways, and receptor-mediated responses, contributing to antitumor and anti-inflammatory actions. The combination is under experimental development for dermatological indications, notably psoriasis.

Other names

caffeine and curcumincurcumin + caffeineCFN + CUR