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Drug intelligence / Profile preview
caffeine + omeprazole + flurbiprofen + dextromethorphan + midazolam
- Development stage
- Phase 1
- Lead developer
- AstraZeneca
- Modality
- Small Molecules
- Administration
- Oral, Rectal, Intranasal, Intramuscular, Intravenous
01
Overview
A combination of five distinct drugs: caffeine (a stimulant), omeprazole (a proton pump inhibitor), flurbiprofen (a non-steroidal anti-inflammatory drug), dextromethorphan (a cough suppressant), and midazolam (a benzodiazepine). This combination is not a standard therapeutic regimen and would require careful medical supervision due to potential interactions between the components.
02
Targets
ADORA1 (Adenosine receptor A1 subtype)ADORA2A (Adenosine A₂A Receptor)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)BZD site (GABA-A receptor benzodiazepine site)ATP4A (Potassium–transporting ATPase alpha chain 1)N-methyl-D-aspartate receptor phencyclidine/channel siteSERT (Sodium-dependent serotonin transporter)SIGMAR1 (Sigma non-opioid intracellular receptor 1)ADOR (Adenosine receptors)GABA-B (Gamma-aminobutyric acid receptor type B)NMDAR (Glutamate receptor ionotropic, NMDA)
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