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Drug intelligence / Profile preview
caffeine sodium benzoate
- Development stage
- Approved
- Lead developer
- Karolinska University Hospital
- Modality
- Small Molecules
- Administration
- Intramuscular, Intravenous
01
Overview
Caffeine sodium benzoate is a small-molecule injectable drug composed of caffeine anhydrous and sodium benzoate, which acts as a solubilizing agent. It functions primarily as a non-selective antagonist at the adenosine A1 and A2a receptors, and it also inhibits D-amino-acid oxidase (DAAO). These actions result in significant central nervous system (CNS) and skeletal muscle stimulation. Historically, the drug has been used to treat respiratory depression associated with CNS depressant overdose. More recently, it has been investigated in Phase 1 clinical trials by Karolinska University Hospital for its analgesic properties in experimental ischemic pain models to determine whether its effects are mediated through central or peripheral mechanisms.
- Other names
- Caffeine and Sodium Benzoate Injection, USPcaffeine sodium benzoate injection
02
Targets
ADORA1 (Adenosine receptor A1 subtype)ADORA2A (Adenosine A₂A Receptor)DAO (D-amino-acid oxidase)
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