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Caffeinol is a combination drug consisting of caffeine and ethanol, primarily investigated for its neuroprotective and anticonvulsive properties. It has been studied as a potential treatment for acute ischemic stroke and traumatic brain injury. Its mechanism of action is believed to involve antagonism of N-methyl-D-aspartate (NMDA) receptors, with caffeine augmenting the anti-ischemic effects of NMDA receptor blockers. Preclinical studies have shown Caffeinol to reduce cortical damage and improve neurological outcomes, and it has advanced to pilot clinical trials in humans for acute ischemic stroke.
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