caflanone

Caflanone is a small molecule, prenylated flavonoid derived from *Cannabis sativa*, specifically identified in the rare Jamaican strain "Black Swan". It is also known as FBL-03G and Isocannflavin B. Caflanone acts primarily as an antagonist of the colony-stimulating factor 1 receptor (CSF1R), thereby modulating macrophage activity and immune responses. Preclinical studies have demonstrated its anticancer properties through induction of apoptosis, cell cycle arrest at G0/G1 phase, inhibition of tumor progression (notably in pancreatic cancer models), and enhancement of anti-tumor immune responses. Caflanone has also shown anti-inflammatory and antiviral activities due to its antioxidant properties. The compound was developed by Flavocure Biotech and has received orphan drug designation from the FDA for pancreatic cancer[2][7][8][9].

Other names

Isocannflavin B4h-1-benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-