CAL-05CR

CAL-05CR is an injectable, intra-articular sustained-release formulation developed for the treatment of moderate to severe osteoarthritis pain. It utilizes verapamil, a calcium channel blocker, embedded in biodegradable polymer microspheres to provide continuous local delivery directly within the joint. The mechanism of action involves regulation of calcium ion channels implicated in osteoarthritis degeneration; by interfering with these channels, verapamil reduces the release of harmful enzymes and inflammation, thereby preserving joint function and providing long-lasting pain relief. This approach aims to minimize systemic side effects and reduce injection frequency compared to traditional therapies[1][6].