calcipotriol + beclomethasone dipropionate

Calcipotriol + beclomethasone dipropionate is a fixed-dose combination topical medication used primarily for the treatment of plaque psoriasis. It combines calcipotriol (also known as calcipotriene), a synthetic vitamin D3 analog that regulates keratinocyte proliferation and differentiation to reduce scaling and plaque formation, with beclomethasone dipropionate (often formulated as betamethasone dipropionate in marketed products), a potent corticosteroid that suppresses inflammation by inhibiting multiple inflammatory cytokines and mediators. The dual mechanism targets both abnormal skin cell growth and inflammation fundamental to psoriasis pathogenesis. This combination is available in various topical formulations including ointment, cream, gel, foam/aerosol spray, and suspension. Clinical studies have demonstrated its superior efficacy over monotherapy with either component alone while maintaining a favorable safety profile[2][5][6][7]. The product is approved for use in adults (and adolescents 12 years or older for some formulations) with mild-to-moderate plaque psoriasis affecting the body or scalp.

Brand names

TaclonexEnstilarDovobetDaivobetWynzora

Other names

calcipotriene + betamethasone dipropionateCal/BDPCal/BD