calcipotriol + betamethasone + urea

This drug is a **topical combination formulation** containing **calcipotriol** (a synthetic vitamin D3 analogue), **betamethasone** (a potent synthetic corticosteroid, typically as betamethasone dipropionate), and **urea** (a keratolytic and hydrating agent). Calcipotriol modulates keratinocyte differentiation and proliferation, betamethasone exerts anti-inflammatory, immunosuppressive, and antiproliferative effects, and urea increases skin hydration and promotes desquamation of scaly plaques. This combination is primarily developed and indicated for the **topical treatment of plaque psoriasis**, especially chronic, scaly, and thickened lesions. The specific addition of urea aims to enhance skin penetration and therapeutic response by softening keratin and improving the delivery of the active pharmaceutical ingredients.