calcipotriol + platelet-rich plasma

**Calcipotriol + platelet-rich plasma** is an investigational combination therapy comprising calcipotriol, a synthetic vitamin D3 analogue, and platelet-rich plasma (PRP), an autologous blood-derived product rich in platelets and growth factors. Calcipotriol primarily modulates keratinocyte proliferation and differentiation by binding to and activating the vitamin D receptor, thereby exerting anti-proliferative and immunomodulatory effects. Platelet-rich plasma, prepared from centrifuged patient blood, contains concentrated platelets that, upon activation, release growth factors (PDGF, TGF-β, IGF, FGF, VEGF) and cytokines, stimulating local tissue repair, immunomodulation, and anti-inflammatory actions[1][2][3]. The combination aims to harness complementary mechanisms to enhance efficacy in diseases such as plaque psoriasis and alopecia areata. The dual modality utilizes calcipotriol's direct action on keratinocyte and immune cell biology, and PRP’s regenerative and anti-inflammatory properties, potentially leading to superior clinical outcomes when used together[1][4].

Other names

topical vitamin D3 analogue + PRP