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calcium (13C)carbonate
- Development stage
- Phase 2
- Lead developer
- Otsuka Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Calcium (13C)carbonate is a stable isotope-labeled diagnostic agent developed by Otsuka Pharmaceutical for the quantitative assessment of gastric acid secretion. Administered orally as part of the C13-CAC breath test, the compound reacts with hydrochloric acid (gastric acid) in the stomach to generate carbon-13-labeled carbon dioxide (13CO2). The labeled gas is absorbed into the bloodstream, exhaled through the lungs, and measured in breath samples using an infrared spectral analyzer. This non-invasive diagnostic tool is used to estimate gastric acidity and evaluate gastric acid-related disorders, such as gastroesophageal reflux disease (GERD) and peptic ulcers, as well as to monitor the pharmacodynamic effects of acid-suppressing therapies like proton pump inhibitors (PPIs) and potassium-competitive acid blockers (P-CABs).
- Other names
- 13C-calcium carbonatecalcium [13C]carbonatecalcium carbonate-13Ccarbonic-13C acid, calcium salt
02
Targets
ATP4A (Potassium–transporting ATPase alpha chain 1)PEP (Pepsin)
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