Drug intelligence / Profile preview

calcium aspartate

Development stage
Unknown
Lead developer
NIPRO
Modality
Small Molecules
Administration
Oral
01

Overview

Calcium L-aspartate is a chelated calcium salt of the amino acid L-aspartic acid, primarily utilized as a highly bioavailable calcium supplement. Unlike inorganic calcium salts such as calcium carbonate, calcium L-aspartate is absorbed more efficiently in the gastrointestinal tract, a process facilitated by the upregulation of calcium transport channels including **TRPV5** and **TRPV6**. Clinically, it is employed in the management and prevention of calcium deficiency-related conditions, such as **osteoporosis** and **osteomalacia**, often in combination with vitamin D analogs. Research has also demonstrated its potential in reducing vascular sensitivity to angiotensin II in pregnant women, suggesting a role in preventing **pregnancy-induced hypertension**. Beyond its therapeutic applications, it has been investigated for environmental and industrial uses, including enhancing plant tolerance to heavy metal toxicity and inhibiting microbial corrosion of carbon steel.

Brand names
ASPARA-CACalciretard
Other names
calcium L-aspartateL-aspartic acid, calcium saltcalcium bis(L-aspartate)
02

Targets

TRPV (TRPV channel family)TRPV6 (Transient receptor potential cation channel subfamily V member 6)CaSR (Extracellular calcium-sensing receptor)

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