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calcium carbonate + magnesium hydroxide + lansoprazole

Development stage
Unknown
Lead developer
Takeda
Modality
Small Molecules
Administration
Oral
01

Overview

This is a combination drug consisting of three active ingredients: - **Calcium carbonate** and **magnesium hydroxide** are antacids that neutralize stomach acid, providing rapid relief from symptoms such as indigestion, heartburn, and upset stomach. They work by directly reacting with gastric hydrochloric acid to form water and salts, thereby increasing gastric pH and reducing irritation of the gastrointestinal mucosa[1][8]. - **Lansoprazole** is a proton pump inhibitor (PPI) that suppresses gastric acid secretion by inhibiting the H+/K+ ATPase enzyme system at the secretory surface of gastric parietal cells. This leads to a more prolonged reduction in stomach acidity compared to antacids alone. Lansoprazole is used for conditions such as gastroesophageal reflux disease (GERD), peptic ulcers, erosive esophagitis, Zollinger-Ellison syndrome, and for Helicobacter pylori eradication in combination regimens[5][7]. This triple combination would theoretically provide both immediate symptom relief (from the antacids) and longer-term suppression of acid production (from lansoprazole). However, there are no widely recognized or marketed products containing all three agents together; combinations with two components are common.

Other names
Lansoprazole/Antacid Combination
02

Targets

ATP4A (Potassium–transporting ATPase alpha chain 1)

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