Drug intelligence / Profile preview

calcium carbonate + magnesium hydroxide + simethicone

Development stage
Unknown
Lead developer
Taiho Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

**Calcium carbonate + magnesium hydroxide + simethicone** is an over-the-counter combination antacid and antiflatulent medication used to relieve symptoms of heartburn, acid indigestion, upset stomach, and gas-associated discomfort such as bloating and pressure. **Calcium carbonate** and **magnesium hydroxide** act as antacids by neutralizing excess gastric hydrochloric acid to raise stomach pH and alleviate acid-related symptoms, while **simethicone** (also known as dimethicone) reduces gas by lowering surface tension of bubbles in the stomach and intestines, promoting their coalescence and expulsion. Available in oral liquid (e.g., 1200 mg calcium carbonate, 270 mg magnesium hydroxide, 80 mg simethicone per 10 mL) and chewable tablet forms (e.g., 675 mg calcium carbonate, 135 mg magnesium hydroxide, 60 mg simethicone per tablet), it is indicated for adults and children 12 years and older, with dosing of 10-20 mL liquid or equivalent tablets between meals, at bedtime, or as directed, not exceeding maximum daily limits.[1][4]

Brand names
Mylanta Coat and CoolRolaids Multi-Symptom
Other names
calcium carbonate, magnesium hydroxide, simethicone liquidcalcium carbonate, magnesium hydroxide, simethicone tablet, chewable
02

Targets

Gas–liquid interface of gastrointestinal gas bubbles

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