Drug intelligence / Profile preview

calcium hypophosphite

Development stage
Unknown
Lead developer
Dr. Wolff
Modality
Small Molecules
Administration
Topical
01

Overview

Calcium hypophosphite is an inorganic salt being investigated for its remineralizing properties in dental care. Developed by researchers associated with the Dr. Wolff Group, it is primarily formulated into toothpastes as a fluoride-free alternative for the prevention of dental caries. The compound acts as a source of calcium and phosphate ions, which are critical for the repair and maintenance of tooth enamel. By promoting the deposition of mineral phases onto demineralized tooth surfaces, calcium hypophosphite helps to restore enamel integrity and inhibit the progression of decay. It has been evaluated in large-scale clinical trials to demonstrate non-inferiority to standard fluoride-containing toothpastes.

Other names
calcium phosphinatecalcium bis(phosphinate)phosphinic acid, calcium salt

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