calcium ionophore A23187

Calcium ionophore A23187 is a polyether carboxylic acid antibiotic produced by fermentation of Streptomyces chartreusensis. It acts as a mobile ion-carrier (ionophore) that forms stable complexes with divalent cations—most selectively with Mn2+, followed by Ca2+ and Mg2+. By facilitating the transport of calcium ions across cell membranes, it increases intracellular calcium concentrations. This property makes it widely used in research to manipulate intracellular calcium levels and study cellular processes regulated by calcium signaling such as signal transduction, secretion, apoptosis, autophagy induction, and oocyte activation after ICSI in reproductive medicine. It also has antibiotic activity against Gram-positive bacteria and fungi[1][2][3][5][9][10].

Other names

Calcium ionophoreCalimycinAntibiotic A 23187