calcium ketophenylpyruvate

Calcium ketophenylpyruvate, often referred to by the translation "calcium ketate" in Chinese pharmaceutical contexts, is a calcium salt of the alpha-keto analog of the essential amino acid phenylalanine. It is an active pharmaceutical ingredient (API) manufactured by Nanjing Baijingyu Pharmaceutical for use in compound alpha-ketoacid tablets, which are indicated for the treatment of protein metabolism disorders associated with chronic kidney disease (CKD). The compound acts as a nitrogen-sparing precursor; upon ingestion, it undergoes transamination to form phenylalanine, a process that utilizes nitrogen from non-essential amino acids. This mechanism helps to reduce the production of urea and the overall nitrogenous waste load on the kidneys, thereby slowing the progression of renal dysfunction and alleviating uremic symptoms.

Other names

calcium ketatealpha-ketophenylpropionate calciumcalcium 2-oxo-3-phenylpropionatecalcium2-oxo-3-phenylpropionatecalcium-2-oxo-3-phenylpropionatecalcium ketophenylpropionatecalcium ketophenylpyruvate API