Drug intelligence / Profile preview

calcium malate

Development stage
Approved
Lead developer
Balchem
Modality
Small Molecules
Administration
Oral
01

Overview

Calcium malate is a highly bioavailable organic calcium salt composed of calcium bound to malic acid. It is widely utilized as a dietary supplement and food additive (E352) to support bone density, skeletal health, muscle contraction, and nerve transmission. Compared to traditional calcium supplements like calcium carbonate, calcium malate exhibits superior water solubility and intestinal absorption, even in higher pH environments, making it gentler on the gastrointestinal tract and less likely to cause bloating, gas, or constipation. It is commonly formulated in supplements to prevent or treat calcium deficiency, osteopenia, and osteoporosis, particularly in postmenopausal women, individuals on dairy-free diets, and bariatric surgery patients.

Brand names
DimaCal
Other names
calcium 2-hydroxybutanedioatecalcium2-hydroxybutanedioatecalcium-2-hydroxybutanedioatecalcium 3-carboxy-2-hydroxypropionatecalcium3-carboxy-2-hydroxypropionatecalcium-3-carboxy-2-hydroxypropionatecalcium DL-malatedi-calcium malatedicalcium malate
02

Targets

CaSR (Extracellular calcium-sensing receptor)

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