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Drug intelligence / Profile preview
calcium-sensing receptor small interfering RNA
- Development stage
- Unknown
- Lead developer
- George Washington University
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Implant
01
Overview
Calcium-sensing receptor small interfering RNA (CaSR siRNA) is a research-use-only double-stranded RNA molecule designed to specifically knock down the expression of the G-protein coupled calcium-sensing receptor (CaSR). In laboratory settings, CaSR siRNA is utilized to study the physiological and pathological roles of CaSR in various tissues, such as the renal proximal tubules, vascular smooth muscle cells, and adipocytes. For instance, in preclinical models, renal subcapsular infusion of CaSR siRNA has been shown to inhibit CaSR-mediated transcellular calcium transport in proximal tubules, leading to decreased calcium influx, diminished tubular calcium reabsorption, and subsequent calcium phosphate crystalluria. It is primarily used as a laboratory tool to investigate calcium homeostasis, vascular calcification, and cellular signaling pathways.
- Other names
- CASR-siRNACaSR siRNAcalcium-sensing receptor siRNA
02
Targets
CaSR (Extracellular calcium-sensing receptor)
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