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calcium sodium phosphosilicate + sodium monofluorophosphate
- Development stage
- Unknown
- Lead developer
- GSK
- Modality
- Small Molecules
- Administration
- Dental, Topical
01
Overview
Calcium sodium phosphosilicate + sodium monofluorophosphate is a therapeutic dental combination developed by GSK Consumer Healthcare for the management of dentin hypersensitivity and the prevention of dental caries. The formulation combines **calcium sodium phosphosilicate (CSPS)**, a bioactive glass material marketed under the brand name **NovaMin**, with **sodium monofluorophosphate (SMFP)**, a fluoride source. CSPS works by reacting with saliva to release calcium and phosphate ions, which form a resilient hydroxyapatite-like layer that physically occludes exposed dentin tubules, thereby blocking the hydrodynamic triggers of tooth sensitivity. Simultaneously, SMFP provides fluoride ions that promote enamel remineralization and enhance resistance to acid-induced demineralization (anticaries effect). This combination is widely utilized in specialized dentifrice products globally.
- Brand names
- Sensodyne Repair & ProtectSensodyne Complete Protection
- Other names
- NovaMin + sodium monofluorophosphateCSPS + SMFPcalcium sodium phosphosilicate + sodium monofluorophosphate
02
Targets
ENO (Alpha-enolase)
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