Drug intelligence / Profile preview

calcium threonate

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

Calcium threonate is a small molecule and a calcium salt of threnoic acid developed as both a novel drug for the treatment of osteoporosis and as a dietary supplement to address calcium deficiency. The most common form is calcium L-threonate ((2R,3S)-2,3,4-trihydroxy butyric acid calcium). It acts by dissociating into calcium and L-threonic acid; the latter is an active metabolite of vitamin C that stimulates vitamin C uptake in cells. This action may enhance osteoblast formation and collagen synthesis via increased vitamin C retention—processes important for bone mineralization. Human studies have demonstrated that it is absorbed after oral administration[1][2][3][5].

Other names
calcium (2R,3S)-2,3,4-trihydroxybutanoate
02

Targets

SLC23A1 (Solute carrier family 23 member 1)

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